How to get to Marsala by car? Marsala has 3 large road accesses that make it easily accessible from any city, north from Trapani, east from Salemi and south from Mazara del Vallo.

The three main ways to reach Marsala by car are the E90 and continuing on the A29 towards Marsala, the E90 towards Mazara del Vallo and then continue on the SS115 to Marsala or via the SS188 from Salemi towards Marsala.